Drug Docking Studies / Structure based Drug Design

  • Target Validation of proteins involved in various biochemical pathways.

  • Virtual Screening of ligands in chemical databases against Protein Targets.

  • Docking of Small molecule ligands and peptides against protein targets of known structure and computing their binding free energy.

  • Homology modeling of protein targets whose structure is not yet determined.

  • Docking of Small molecule ligands and peptides against modeled protein structures and computing their binding free energy.

SAR / QSAR Studies (Pharmacophore mapping)

  • LIGAND BASED RATIONAL DRUG DESIGN - Structure-activity relationship and Quantitative Structure-activity Relationship approaches in Computer-Aided Drug Design.

Bio-Molecular Simulations

  • Molecular Dynamic Simulations of proteins in different conditions.

  • Calculating the free energy change of enzyme mutants.

  • Accurate calculation of binding free energy of protein-drug complexes.

  • Calculating other thermodynamic parameters like enthalpy change and conformational entropy change from MD trajectories. 

Protein Engineering

  • Design of Stable Proteins and Enzymes for industrial applications.

  • Predicting the Thermo-stability of enzyme mutants.

  • Predicting the stability of enzymes/proteins at altered pH conditions, ionic strengths and in presence of organic solvents.

  • Site-directed Mutagenesis - Design of oligonucleotide  primers for to introduce specific mutations in proteins/enzymes.

  • Design of site-specific mutations and smart libraries in protein engineering.

  • Disulfide engineering in proteins to increase stability.

  • Design of enzyme mutants to overcome product inhibition.

HPLC

  • Analysis of pharmaceutical compounds and natural phytochemicals, peptides and proteins.

  • Purification of peptides/phytochemicals using HPLC.

Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry based Analysis

  • Structure determination of small molecule ligands and peptides using NMR, IR and Mass Spectrometry.

  • Interpretation of Mass Spectrometric Data of ligands, peptides and proteins.

  • Interpretation of NMR Data of ligands, peptides and proteins.

  • Study of Protein dynamics using NMR.

  • Study of Protein-drug interactions and Protein-protein interactions using NMR and HDX based Mass Spectrometry.

Omics Data Analysis

  • Genomics - Next Generation Sequencing (NGS) Data Analysis.

  • Transcriptomics - MicroArray Data Analysis and SAGE Data Analysis.

  • Proteomics - Image Processing of 2D gels, Protein Sequencing using mass spectrometry, Protein Identification and their Post Translational Modifications using Mass spectrometry, Interpretation of Proteomics Data.

  • Quantitative Proteomics and Targeted Proteomics.

  • Metabalomics - Identification of metabolites from clinical samples.

Fermentation Technology

  • Statistical optimization of various parameters in fermentation. 

  • Expression of Recombinant Proteins in fermenters.

  • Design and optimization of Solid-state fermenters.

Training/Internships/Projects

  • BIOINFORMATICS - Drug Design, Bioinformatics approaches in CRISPR Technology, Protein Engineering, Computational Genomics and Proteomics.

  • HPLC Training - HPLC based purification and analysis of pharmaceuticals, natural phytochemicals and peptides.

  • Training in NMR and Mass Spectrometry Data Analysis.

  • Training in Fermentation Technology.

  • Training in CRISPR Technology.

Workshops and Popular Talks

  • Regular workshops on CRISPR Technology, Drug Design and Development, UNIX for biologists, Protein Engineering, Bio-molecular simulations in Drug Discovery, Structural Biology.

Courses

  • Certificate course on CRISPR/CAS9 Technology.

  • Certificate course on Drug Design.

Coaching Classes for Competitive Entrance Exams

  • GATE (Biotechnology/Life Sciences)

  • GPAT

  • CSIR/ICMR JRF

  • NEET and other Medical Entrance Exams

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Our Services include

CRISPR CAS9 GENOME EDITING OF MICROBES & MAMMALIAN CELL LINES FOR INDUSTRIAL AND RESEARCH APPLICATIONS

 

GENOMICS DATA ANALYSIS

 

PROTEIN ENGINEERING - RATIONAL DESIGN BY CRISPR CAS9 & SITE DIRECTED MUTAGENESIS.

 MOLECULAR DYNAMIC SIMULATIONS OF   PROTEIN-DRUG COMPLEXES

 PROTEOMICS - 2D Gel Electrophoresis / MS Data Analysis

     

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 SMALL MOLECULE / PEPTIDE STRUCTURE ELUCIDATION USING SPECTROSCOPY

 

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