Drug Docking Studies / Structure based Drug Design

• Target Validation of proteins involved in various biochemical pathways.

• Virtual Screening of ligands in chemical databases against Protein Targets.

• Docking of Small molecule ligands and peptides against protein targets of known structure and computing their binding free energy.

• Homology modeling of protein targets whose structure is not yet determined.

• Docking of Small molecule ligands and peptides against modeled protein structures and computing their binding free energy.

SAR / QSAR Studies (Pharmacophore mapping)

• LIGAND BASED RATIONAL DRUG DESIGN - Structure-activity relationship and Quantitative Structure-activity Relationship approaches in Computer-Aided Drug Design.

Bio-Molecular Simulations

• Molecular Dynamic Simulations of proteins in different conditions.

• Calculating the free energy change of enzyme mutants.

• Accurate calculation of binding free energy of protein-drug complexes.

• Calculating other thermodynamic parameters like enthalpy change and conformational entropy change from MD trajectories. 

Protein Engineering

• Design of Stable Proteins and Enzymes for industrial applications.

• Predicting the Thermo-stability of enzyme mutants.

• Predicting the stability of enzymes/proteins at altered pH conditions, ionic strengths and in presence of organic solvents.

• Site-directed Mutagenesis - Design of oligonucleotide  primers for to introduce specific mutations in proteins/enzymes.

• Design of site-specific mutations and smart libraries in protein engineering.

• Disulfide engineering in proteins to increase stability.

• Design of enzyme mutants to overcome product inhibition.

HPLC

• Analysis of pharmaceutical compounds and natural phytochemicals, peptides and proteins.

• Purification of peptides/phytochemicals using HPLC.

Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry based Analysis

• Structure determination of small molecule ligands and peptides using NMR, IR and Mass Spectrometry.

• Interpretation of Mass Spectrometric Data of ligands, peptides and proteins.

• Interpretation of NMR Data of ligands, peptides and proteins.

• Study of Protein dynamics using NMR.

• Study of Protein-drug interactions and Protein-protein interactions using NMR and HDX based Mass Spectrometry.

Omics Data Analysis

• Genomics - Next Generation Sequencing (NGS) Data Analysis.

• Transcriptomics - MicroArray Data Analysis and SAGE Data Analysis.

• Proteomics - Image Processing of 2D gels, Protein Sequencing using mass spectrometry, Protein Identification and their Post Translational Modifications using Mass spectrometry, Interpretation of Proteomics Data.

• Quantitative Proteomics and Targeted Proteomics.

• Metabalomics - Identification of metabolites from clinical samples.

Fermentation Technology

• Statistical optimization of various parameters in fermentation. 

• Expression of Recombinant Proteins in fermenters.

• Design and optimization of Solid-state fermenters.

Training/Internships/Projects

• BIOINFORMATICS - Drug Design, Bioinformatics approaches in CRISPR Technology, Protein Engineering, Computational Genomics and Proteomics.

• HPLC Training - HPLC based purification and analysis of pharmaceuticals, natural phytochemicals and peptides.

• Training in NMR and Mass Spectrometry Data Analysis.

• Training in Fermentation Technology.

• Training in CRISPR Technology.

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Workshops and Popular Talks

• Regular workshops on CRISPR Technology, Drug Design and Development, UNIX for biologists, Protein Engineering, Bio-molecular simulations in Drug Discovery, Structural Biology.

Courses

• Certificate course on CRISPR/CAS9 Technology.

• Certificate course on Drug Design.

Coaching Classes for Competitive Entrance Exams

• GATE (Biotechnology/Life Sciences)

• GPAT

• CSIR/ICMR JRF

• NEET and other Medical Entrance Exams